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Conceptual diagram of modelling approach. The overall model consists of three main components: (1) the <t>DES</t> model that projects the number of product launches and the clinical trial costs, (2) the economic and health benefits model which projects the potential economic and health benefits from product launches and (3) the economic analyses that calculate the BCRs and ICERs of the different design options. BCRs benefit–cost ratio; <t>DES,</t> <t>discrete</t> event simulation; ICERs, incremental cost-effectiveness ratio.
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Conceptual diagram of modelling approach. The overall model consists of three main components: (1) the <t>DES</t> model that projects the number of product launches and the clinical trial costs, (2) the economic and health benefits model which projects the potential economic and health benefits from product launches and (3) the economic analyses that calculate the BCRs and ICERs of the different design options. BCRs benefit–cost ratio; <t>DES,</t> <t>discrete</t> event simulation; ICERs, incremental cost-effectiveness ratio.
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Conceptual diagram of modelling approach. The overall model consists of three main components: (1) the <t>DES</t> model that projects the number of product launches and the clinical trial costs, (2) the economic and health benefits model which projects the potential economic and health benefits from product launches and (3) the economic analyses that calculate the BCRs and ICERs of the different design options. BCRs benefit–cost ratio; <t>DES,</t> <t>discrete</t> event simulation; ICERs, incremental cost-effectiveness ratio.
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simevents-designed to simulate discrete event systems (des)  (MathWorks Inc)
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MathWorks Inc simevents-designed to simulate discrete event systems (des)
Conceptual diagram of modelling approach. The overall model consists of three main components: (1) the <t>DES</t> model that projects the number of product launches and the clinical trial costs, (2) the economic and health benefits model which projects the potential economic and health benefits from product launches and (3) the economic analyses that calculate the BCRs and ICERs of the different design options. BCRs benefit–cost ratio; <t>DES,</t> <t>discrete</t> event simulation; ICERs, incremental cost-effectiveness ratio.
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Conceptual diagram of modelling approach. The overall model consists of three main components: (1) the DES model that projects the number of product launches and the clinical trial costs, (2) the economic and health benefits model which projects the potential economic and health benefits from product launches and (3) the economic analyses that calculate the BCRs and ICERs of the different design options. BCRs benefit–cost ratio; DES, discrete event simulation; ICERs, incremental cost-effectiveness ratio.

Journal: BMJ Global Health

Article Title: Investing in a global pooled-funding mechanism for late-stage clinical trials of poverty-related and neglected diseases: an economic evaluation

doi: 10.1136/bmjgh-2023-011842

Figure Lengend Snippet: Conceptual diagram of modelling approach. The overall model consists of three main components: (1) the DES model that projects the number of product launches and the clinical trial costs, (2) the economic and health benefits model which projects the potential economic and health benefits from product launches and (3) the economic analyses that calculate the BCRs and ICERs of the different design options. BCRs benefit–cost ratio; DES, discrete event simulation; ICERs, incremental cost-effectiveness ratio.

Article Snippet: We developed a discrete event simulation (DES) using the MATLAB-based simulation tool SimEvents ( ).

Techniques: